Harrison's Principles of Internal Medicine, 17th Edit.With DVD

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Table of contents

Contents

Contributors
Preface

Part 1
Introduction to Clinical Medicine

1 The Practice of Medicine
The Editors

2 Global Issues in Medicine
Jim Yong Kim / Paul Farmer

3 Decision-Making in Clinical Medicine
Daniel B. Mark

4 Screening and Preventionof Diseases
Gary J. Martin

5 Principles of Clinical Pharmacology
Dan M. Roden

6 Women’s Health
Andrea Dunaif

7 Medical Disorders during Pregnancy
Robert L. Barbieri / John T. Repke

8 Medical Evaluation of the Surgical Patient
Wei C. Lau / Kim A. Eagle9 Geriatric Medicine
Lisa B. Caruso / Rebecca A. Silliman

10 Complementary and Alternative Medicine
Stephen E. Straus

11 Palliative and End-of-Life Care
Ezekiel J. Emanuel / Joshua Hauser / Linda L. Emanuel

e1 The Safety and Quality of Health Care
David W. Bates

e2 Economic Considerations in the Practice of Medicine
David Meltzer

e3 Racial and Ethnic Disparities in Health Care
Joseph R. Betancourt / David Blumenthal

e4 Ethical Issues in Clinical Medicine
Bernard Lo


Part 2
Cardinal Manifestations and Presentation of DiseasesSection 1
Pain

12 Pain: Pathophysiology and Management
Howard L. Fields / Joseph B. Martin

13 Chest Discomfort
Thomas H. Lee

14 Abdominal Pain
William Silen

15 Headache
Peter J. Goadsby / Neil H. Raskin

16 Back and Neck Pain
John W. Engstrom

Section 2
Alterations in Body Temperature

17 Fever and Hyperthermia
Charles A. Dinarello / Reuven Porat

18 Fever and Rash
Elaine T. Kaye / Kenneth M. Kaye

e5 Atlas of Rashes Associated with Fever
Elaine T. Kaye / Kenneth M. Kaye

19 Fever of Unknown Origin
Jeffery A.Gelfand / Michael V. Callahan

20 Hypothermia and Frostbite
Daniel F. Danzl

Section 3
Nervous System Dysfunction

21 Syncope
Mark D. Carlson

22 Dizziness and Vertigo
Robert B. Daroff

23 Weakness and Paralysis
Michael J. Aminoff

24 Gait and Balance Disorders
Lewis Sudarsky

25 Numbness, Tingling, and Sensory Loss
Michael J. Aminoff / Arthur K.Asbury

26 Confusion and Delirium
S. Andrew Josephson / Bruce L. Miller

e6 Memory Loss
Thomas D. Bird / Bruce L. Miller


27 Aphasia, Memory Loss, and Other Focal Cerebral Disorders
M.-Marsel Mesulam

28 Sleep Disorders
Charles A. Czeisler / John W. Winkleman / Gary S. Richardson


Section 4
Disorders of Eyes, Ears, Nose, and Throat

29 Disorders of the Eye
Jonathan C. Horton

30 Disorders of Smell, Taste, and Hearing
Anil K. Lalwani

31 Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory Infections
Michael A. Rubin / Ralph Gonzales / Merle A. Sande

32 Oral Manifestations of Disease
Samuel C. Durso

e7 Atlas of Oral Manifestations of Disease
Samuel C. Durso / Janet A. Yellowitz

Section 5
Alterations in Circulatory and Respiratory Functions


33 Dyspnea and Pulmonary Edema
Richard M. Schwartzstein

34 Cough and Hemoptysis
Steven E. Weinberger / David A. Lipson

35 Hypoxia and Cyanosis
Eugene Braunwald

36 Edema
Eugene Braunwald / Joseph Loscalzo

e8 Approach to the Patient with a Heart Murmur
Patrick O’Gara / Eugene Braunwald

37 Palpitations
Joseph Loscalzo


Section 6
Alterations in Gastrointestinal Function

38 Dysphagia
Raj K. Goyal

39 Nausea, Vomiting, and Indigestion
William L. Hasler

40 Diarrhea and Constipation
Michael Camilleri / Joseph A. Murray

41 Weight Loss
Carol M. Reife

42 Gastrointestinal Bleeding
Loren Laine

43 Jaundice
Daniel S. Pratt / Marshall M. Kaplan

44 Abdominal Swelling and Ascites
Robert M. Glickman / Roshini Rajapaksa

Section 7
Alterations in Renal and Urinary Tract Function

45 Azotemia and Urinary Abnormalities
Bradley M. Denker / Barry M. Brenner

e9 Atlas of Urinary Sediments and Renal Biopsies
Agnes B. Fogo / Eric G. Neilsen

46 Fluid and Electrolyte Disturbances
Gary G. Singer / Barry M. Brenner

47 Hypercalcemia and Hypocalcemia
Sundeep Khosla

48 Acidosis and Alkalosis
Thomas B. DuBose, Jr.

Section 8
Alterations in Sexual Function and Reproduction

49 Sexual Dysfunction
Kevin T. McVary

50 Hirsutism and Virilization
David A. Ehrmann

51 Menstrual Disorders and Pelvic Pain
Janet E. Hall

Section 9
Alterations in the Skin

52 Approach to the Patient with a Skin Disorder
Thomas J. Lawley / Kim B. Yancey

53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
Calvin O. McCall / Thomas J. Lawley

54 Skin Manifestations of Internal Disease
Jean L. Bolognia / Irwin M. Braverman

55 Immunologically Mediated Skin Diseases
Kim B. Yancey / Thomas J. Lawley

56 Cutaneous Drug Reactions
Jean-Claude Roujeau / Robert S. Stern / Bruce C. Wintroub

57 Photosensitivity and Other Reactions to Light
David R. Bickers

e10 Atlas of Skin Manifestations of Internal Disease
Thomas J. Lawley / Stephen Templeton


Section 10
Hematologic Alterations

58 Anemia and Polycythemia
John W. Adamson / Dan L. Longo

59 Bleeding and Thrombosis
Barbara A. Konkle

60 Enlargement of Lymph Nodes and Spleen
Patrick H. Henry / Dan L. Longo

61 Disorders of Granulocytes and Monocytes
Steven M. Holland /John I. Gallin

e11 Atlas of Hematology and Analysis of Peripheral Blood Smears
Dan L. Longo

Part 3
Genetics and Disease

62 Principles of Human Genetics
J. Larry Jameson / Peter Kopp

63 Chromosome Disorders
Terry Hassold / Stuart Schwartz

64 The Practice of Genetics in Clinical Medicine
Susan Miesfeldt / J. Larry Jameson

65 Gene Therapy in Clinical Medicine
Katherine A. High

Part 4
Regenerative Medicine

66 Stem Cell Biology
Minoru S. H. Ko

67 Applications of Stem Cell Biology in Clinical Medicine
Jack A. Kessler

68 Hematopoietic Stem Cells
David T. Scadden / Dan L. Longo

69 Tissue Engineering
Jennifer Anderson /Joseph P. Vacanti

Part 5
Nutrition

70 Nutritional Requirements and Dietary Assessment
Johanna Dwyer

71 Vitamin and Trace Mineral Deficiency and Excess
Robert M. Russell / Paolo M. Suter


72 Malnutrition and Nutritional Assessment
Douglas C. Heimburger

73 Enteral and Parenteral Nutrition Therapy
Bruce R. Bistrian / David F. Driscoll

74 Biology of Obesity
Jeffrey S. Flier / Eleftheria Maratos-Flier

75 Evaluation and Management of Obesity
Robert F. Kushner

76 Eating Disorders
B. Timothy Walsh




Part 6
Oncology and Hematology

Section 1
Neoplastic Disorders

77 Approach to the Patient with Cancer
Dan L. Longo

78 Prevention and Early Detection of Cancer
Otis W. Brawley / Barnett S. Kramer

79 Cancer Genetics
Pat J. Morin / Jeffrey M. Trent / Francis S. Collins / Bert Vogelstein

80 Cancer Cell Biology and Angiogenesis
Robert G. Fenton / Dan L. Longo

81 Principles of Cancer Treatment
Edward A. Sausville / Dan L. Longo

82 Infections in Patients with Cancer
Robert Finberg

83 Cancer of the Skin
Arthur J. Sober / Hensin Tsao / Carl V. Washington

84 Head and Neck Cancer
Everett E. Vokes

85 Neoplasms of the Lung
John D. Minna / Joan H. Schiller

86 Breast Cancer
Marc E. Lippman

87 Gastrointestinal Tract Center
Robert J. Mayer

88 Tumors of the Liver and Biliary Tree
Brian I. Carr


89 Pancreatic Cancer
Yu Jo Chua / David Cunningham

90 Bladder and Renal Cell Carcinomas
Howard I. Scher / Robert J. Motzer


91 Benign and Malignant Diseases of the Prostate
Howard I. Scher

92 Testicular Cancer
Robert J. Motzer / George J. Bosl

93 Gynecologic Malignancies
Robert C. Young

94 Soft Tissue and Bone Sarcomas and Bone Metastases
Shreyaskumar R. Patel / Robert S. Benjamin

95 Carcinoma of Unknown Primary
Gauri R. Varadhachary /James L. Abbruzzese

96 Paraneoplastic Syndromes: Endocrinologic/Hematologic
J. Larry Jameson / Bruce E. Johnson

97 Paraneoplastic Neurologic Syndromes
Joseph Dalmau / Myrna R. Rosenfeld

e12 Thymoma
Dan L. Longo

e13 Late Consequences of Cancer and Its Treatment
Michael C. Perry / Dan L. Longo


Section 2
Hematopoietic Disorders

98 Iron Deficiency and Other Hypoproliferative Anemias
John W. Adamson

99 Disorders of Hemoglobin
Edward J. Benz

100 Megaloblastic Anemia
A. Victor Hoffbrand

101 Hemolytic Anemias and Anemias due to Acute Blood Loss
Lucio Luzzatto

102 Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes
Neal S. Young

103 Polycythemia Vera and Other Myeloproliferative Diseases
Jerry L. Spivak

104 Acute and Chronic Myeloid Leukemia
Meir Wetzler /John C. Byrd / Clara D. Bloomfield

105 Malignancies of Lymphoid Cells
Dan L. Longo

106 Plasma Cell Disorders
Nikhil C. Munshi / Dan L. Longo / Kenneth C. Anderson

107 Transfusion Biology and Therapy
Jeffery S. Dzieczkowski / Kenneth C. Anderson


108 Hematopoietic Cell Transplantation
Frederick R. Applebaum

Section 3
Disorders of Hemostasis

109 Disorders of Platelets and Vessel Wall
Barbara A. Konkle

110 Coagulation Disorders
Valder Arruda / Katherine High

111 Thrombosis Venous
F.R. Rosendaal / H.R. Büller

112 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs
Jeffery L. Weitz
Part 7
Infectious Diseases

Section 1
Basic Considerations in Infectious Diseases

113 Introduction to Infectious Diseases: Host-Pathogen Interactions
Lawrence C. Madoff / Dennis L. Kasper

114 Molecular Mechanisms of Microbial Pathogenesis
Gerald B. Pier

115 Approach to the Acutely Ill Infected Febrile Patient
Tamar F. Barlam / Dennis L. Kasper

116 Immunization Principles and Vaccine Use
Gerald T. Keusch / Kenneth J. Bart / Mark Miller

117 Health Advice for International Travel
J.S. Keystone / P.E. Kozarsky

e14 Laboratory Diagnosis of Infectious Diseases
Alexander J. McAdam / Andrew B. Onderdonk

Section 2
Clinical Syndromes: Community-Acquired Infections

118 Infective Endocarditis
Adolf W. Karchmer

119 Infections of the Skin, Muscle, and Soft Tissues
Dennis L. Stevens

120 Osteomyelitis
Jeffrey Parsonnet

121 Intraabdominal Infections and Abscesses
Miriam J. Baron / Dennis L. Kasper

122 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
Joan R. Butterton / Stephen B. Calderwood

123 Clostridium difficile-Associated Disease, Including Pseudomembranous Colitis
Dale N. Gerding / Stuart Johnson

124 Sexually Transmitted Infections: Overview and Clinical Approach
King K. Holmes

e15 Infectious Complications of Bites and Burns
Lawrence C. Madoff / Florencia Pereyra

Section 3
Clinical Syndromes: Nosocomial Infections

125 Health Care-Associated Infections
Robert A. Weinstein

126 Infections in Transplant Recipients
Robert Finberg /Joyce Fingeroth


Section 4
Approach to Therapy for Bacterial Diseases

127 Treatment and Prophylaxis of Bacterial Infections
Gordon L. Archer / Ronald E. Polk

Section 5
Diseases Caused by Gram-Positive Bacteria

128 Pneumococcal Infections
Daniel M. Musher

129 Staphylococcal Infections
Franklin D. Lowy

130 Strepococcal and Enterococcal Infections
Michael R. Wessels

131 Diphtheria and Other Infections Caused by Corynebacteria and Related Species
William R. Bishai / Jack R. Murphy

132 Infections Caused by Listeria monocytogenes
Elizabeth L. Hohmann / Daniel A. Portnoy

133 Tetanus
Elias Abrutyn

134 Botulism
Elias Abrutyn

135 Gas Gangrene and Other Clostridial Infections
Dennis L. Kasper /Lawrence C. Madoff


Section 6
Diseases Caused by Gram-Negative Bacteria

136 Meningococcal Infections
Lee M. Wetzler

137 Gonococcal Infections
Sanjay Ram / Peter A. Rice

138 Moraxella Infections
Daniel M. Musher

139 Haemophilus Infections
Timothy F. Murphy

140 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
Tamar F. Barlam / Dennis L. Kasper

141 Legionella Infection
Miguel Sabria / Victor L. Yu

142 Pertussis and Other Bordetella Infections
Scott A. Halperin

143 Diseases Caused by Gram-Negative Enteric Bacilli
Thomas A. Russo / James R. Johnson

144 Helicobacter Pylori Infections
John C. Atherton / Martin J. Blaser

145 Infections Due to Pseudomonas Species and Related Organisms
Reuben Ramphal

146 Salmonellosis
David A. Pegues / Samuel I. Miller

147 Shingellosis
Philippe Sansonetti / Jean Bergounioux

148 Infections Due to Campylobacter and Related Species
Martin J. Blaser

149 Cholera and Other Vibrioses
Matthew K. Waldor / Gerald T. Keusch

150 Brucellosis
Michael J. Corbel / Nicholas J. Beeching

151 Tularemia
Richard F. Jacobs / Gordon E. Schutze

152 Plague and Other Yersnia Infections
David T. Dennis / Grant L. Campbell

153 Bartonella Infections, Including Cat-Scratch Disease
David H. Spach / Emily Darby

154 Donovanosis
Gavin Hart

Section 7
Miscellaneous Bacterial Infections

155 Nocardiosis
Gregory A. Filice

156 Actinomycosis
Thomas A. Russo

157 Infections Due to Mixed Anaerobic Organisms
Dennis L. Kasper / Ronit Cohen-Poradosu

Section 8
Mycobacterial Diseases

158 Tuberculosis
Mario C. Raviglione / Richard J. O’Brien

159 Leprosy (Hansen’s Disease)
Robert H. Gelber

160 Nontuberculous Mycobacteria
C. Fordham von Reyn

161 Antimycobacterial Agents
Richard J. Wallace / David E. Griffith

Section 9
Spirochetal Disease

162 Syphilis
Sheila A. Lukehart

163 Endemic Treponematoses
Sheila A. Lukehart

164 Leptospirosis
Peter Speelman / Rudy Harkskeerl

165 Relapsing Fever
David T. Dennis

166 Lyme Borreliosis
Allen C. Steere
Section 10
Diseases Caused by Rickettsia, Mycoplasma, and Chlamydia

167 Rickettsial Diseases
David H. Walker / J. Stephen Dumler / Thomas Marrie

168 Infections Due to Mycoplasmas
William M. McCormack

169 Chlamydial Infections
Walter E. Stamm

Section 11
Viral Diseases: General Considerations

170 Medical Virology
Fred Wang /Elliott Kieff

171 Antiviral Chemotherapy, Excluding Antiretroviral Drugs
Lindsey R. Baden / Raphael Dolin

Section 12
Infections Due to DNA Viruses


172 Herpes Simplex Viruses
Lawrence Corey

73 Varicella-Zoster Virus Infections
Richard J. Whitley

174 Epstein-Barr Virus Infections, Including Infectious Mononucleosis
Jeffery I. Cohen

175 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8
Martin S. Hirsch

176 Molluscum Contagiosum, Monkeypox and Other Poxviruses Excluding Smallpox Virus
Fred Wang

177 Parvovirus Infections
Kevin E. Brown

178 Human Papillomavirus Infections
Richard C. Reichman

Section 13
Infections Due to DNA and RNA Respiratory Viruses


179 Common Viral Respiratory Infections and Severe Acute Respiratory Syndrome (SARS)
Raphael Dolin

180 Influenza
Raphael Dolin

Section 14
Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses

181 The Human Retroviruses
Dan L. Longo /Anthony S. Fauci

182 Human Immunodeficiency Virus Disease: AIDS and Related Disorders
Anthony S. Fauci / H. Clifford Lane


Section 15
Infections Due to RNA Viruses

183 Viral Gastroenteritis
Umesh D. Parashar / Roger I. Glass

184 Enterovirus and Reoviruses Infections
Jeffery I. Cohen

185 Measles (Rubeola)
Anne Gershon


186 Rubella (German Measles)
Anne Gershon

187 Mumps
Anne Gershon

188 Rabies and Other Rhabdovirus Infections
Alan C. Jackson / Eric C. Johannsen

189 Infections Caused by Arthropod and Rodent-Borne Viruses
Clarence J. Peters

190 Ebola and Marburg Viruses
Clarence J. Peters


Section 16
Fungal and Algal Infections

191 Diagnosis and Treatment of Fungal Infections
John E. Edwards

192 Histoplasmosis
Chadi A. Hage / L. Joseph Wheat

193 Coccidioidomycosis
Neil M. Ampel

194 Blastomycosis
Stanley W. Chapman

195 Cryptococcosis
Arturo Casadevall

196 Candidiasois
John E. Edwards

197 Aspergillosis
David W. Denning

198 Mucormycosis
Alan M. Sugar

199 Miscellaneous Mycoses and Algal Infections
Stanley W. Chapman / Donna C. Sullivan

200 Pneumocystis Infection
A. Geroge Smulian /Peter D. Walzer


Section 17
Protozoal and Helminthic Infections: General Considerations

e16 Laboratory Diagnosis of Parasitic Infections
Sharon L. Reed / Charles E. Davis

201 Agents Used to Treat Parasitic Infections
Thomas A. Moore

e17 Pharmacology of Agents Used to Treat Parasitic Infections
Thomas A. Moore

Section 18
Protozoal Infections

202 Ambiasis and Infection with Free-Living Amebas
Sharon L. Reed

203 Malaria
Nicholas J. White / Joel G. Breman

204 Babesiosis
Jeffery Gelfand

e18 Atlas of Blood Smears of Malaria and Babesiosis
Nicholas J. White / Joel G. Breman

205 Leishmaniasis
Barbara L. Herwaldt

206 Trypanosomiasis
Louis V. Kirchhoff

207 Toxoplasma Infections
Lloyd H. Kasper

208 Protozoal Intestinal Infections and Trichomoniasis
Peter F. Weller


Section 19
Helminthic Infections

209 Trichinella and Other Tissue Nematodes
Peter F. Weller

210 Intestinal Nematodes
Peter F. Weller /Thomas B. Nutman

211 Filarial and Related Infections
Peter F. Weller / Thomas B. Nutman

212 Schistosomiasis and Other Trematode Infections
Adel A.F. Mahmoud

213 Cestodes
A. Clinton White, Jr. / Peter F. Weller



Part 8
Bioterrorism and Clinical Medicine

214 Microbioterrorism
H. Clifford Lane / Anthony S. Fauci

215 Chemical Bioterrorism
Charles G. Hurst / Jonathan Newmark / James A. Romano

216 Radiation Bioterrorism
Zelig A. Tochner / Eli Glatstein



Part 9
Disorders of Cardiovascular System



Section 1
Introduction to Cardiovascular Disorders

217 Basic Biology of the Cardiovascular System
Joseph Loscalzo / Peter Libby / Eugene Braunwald

218 Epidemiology of Cardiovascular Disease
Thomas A. Gaziano / J. Michael Gaziano

219 Approach to the Patient with Possible Cardiovascular Disease
Eugene Braunwald


Section 2
Diagnosis of Cardiovascular Disorders

220 Physical Examination of the Cardiovascular System
Robert A. O’Rourke /Eugene Braunwald

221 Electrocardiography
Ary L. Goldberger

e19 Atlas of Electrocardiography
Ary L. Goldberger

222 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT Imaging
Rick Nishimura / Raymond J. Gibbons / James F. Glockner /A. Jamil Tajik

e20 Atlas of Noninvasive Cardiac Imaging
Rick Nishimura

223 Diagnostic Cardiac Catheterization and Angiography
Donald S. Baim


Section 3
Disorders of Rhythm

224 Principles of Electrophysiology
Gordon F. Tomaselli

225 The Bradyarrhythmias
Gordon F. Tomaselli

226 The Tachyarrhythmias
Francis Marchlinksi

e21 Atlas of Cardiac Arrhythmias
Ary L. Goldberger

Section 4
Disorders of the Heart

227 Heart Failure and Cor Pulmonale
Douglas L. Mann

228 Cardiac Transplantation and Prolonged Assisted Circulation
Sharon A. Hunt

229 Congenital Heart Disease in the Adult
John S. Child

230 Valvular Heart Disease
Patrick O’Gara / Eugene Braunwald

231 Cardiomyopathy and Myocarditis
Joshua Wynne / Eugene Braunwald

232 Pericardial Disease
Eugene Braunwald

233 Tumors and Trauma of the Heart
Eric H. Awtry / Wilson S. Colucci

234 Cardiac Manifestations of Systemic Disease
Eric H. Awtry / Wilson S. Colucci


Section 5
Vascular Disease

235 The Pathogenesis, Prevention, and Treatment of Atherosclerosis
Peter Libby

e22 Atlas of Atherosclerosis
Peter Libby

236 The Metabolic Syndrome
Robert H. Eckel

237 Ischemic Heart Disease
Elliott M. Antman / Andrew P. Selwyn/ Eugene Braunwald / Joseph Loscalzo

238 Unstable Angina and Non-ST-Elevation Myocardial Infarction
Christopher P. Cannon / Eugene Braunwald

239 ST-Segment Elevation Myocardial Infarction
Elliott M. Antman / Eugene Braunwald

240 Percutaneous Coronary Intervention
Donald S. Baim

e23 Atlas of Percutaneous Revascularization
Donald S. Baim

241 Hypertensive Vascular Disease
Ted A. Kotchen

242 Diseases of the Aorta
Mark A. Creager / Joseph Loscalzo

243 Vascular Diseases of the Extremities
Mark A. Creager / Joseph Loscalzo

244 Pulmonary Hypertension
Stuart Rich


Part 10
Disorders of the Respiratory System

Section 1
Diagnosis of Respiratory Disorders

245 Approach to the Patient with Disease of the Respiratory System
David A. Lipson / Steven E. Weinberger

246 Disturbances of Respiratory Function
Steven E. Weinberger /Ilene M. Rosen

247 Diagnostic Procedures in Respiratory Diseases
Scott Manaker / Steven E. Weinberger

e24 Atlas of Chest Imaging
Patricia Kritek / John J. Reilly, Jr.

Section 2
Diseases of the Respiratory System

248 Asthma
Peter J. Barnes

249 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia
Joel N. Kline / Gary W. Hunninghake

250 Environmental Lung Disease
Frank E. Speizer / John R. Balmes

251 Pneumonia
Lionel A. Mandell / Richard Wunderink

252 Bronchiectasis and Lung Abscess
Gregory Tino / Steven E. Weinberger

253 Cystic Fibrosis
Richard C. Boucher

254 Chronic Obstructive Pulmonary Disease
John J. Reilly, Jr. / Edwin K. Silverman / Steven D. Shapiro

255 Interstitial Lung Diseases
Talmadge E. King, Jr.

256 Deep Venous Thrombosis and Pulmonary Thromboembolism
Samuel Z. Goldhaber

257 Disorders of the Pleura and Mediastinum
Richard W. Light

258 Disorders of Ventilation
Eliot A. Phillipson



259 Sleep Apnea
Neil J. Douglas

260 Lung Transplantation
Elbert P. Trulock


Part 11
Critical Care Medicine


Section 1
Respiratory Critical Care


261 Principles of Critical Care Medicine
John P. Kress / Jesse B. Hall

262 Acute Respiratory Distress Syndrome
Bruce D. Levy / Steve D. Shapiro

263 Mechanical Ventilatory Support
Edward P. Ingenito


Section 2
Shock and Cardiac Arrest


264 Approach to the Patient with Shock
Ronald V. Maier

265 Severe Sepsis and Septic Shock
Robert S. Munford

266 Cardiogenic Shock and Pulmonary Edema
Judith S. Hochman / David H. Ingbar

267 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death
Robert J. Myerberg / Agustin Castellanos


Section 3
Neurologic Critical Care


268 Coma
Allan H. Ropper

269 Neurologic Critical Care, Including Hypoxic-Ischemic Encephalopathy and Subarachnoid Hemorrhage
J. Claude Hemphill / Wade S. Smith


Section 4
Oncologic Emergencies

270 Oncologic Emergencies
Rasim Gucalp / Janice Dutcher


Part 12
Disorders of the Kidney and Urinary Tract


271 Cellular and Molecular Biology of the Kidney
Alfred L. George / Eric G. Neilson

272 Adaptation of the Kidney to Renal Injury
Raymond C. Harris / Eric G. Neilson

273 Acute Renal Failure
Kathleen D. Liu / Glenn M. Chertow

274 Chronic Kidney Disease
Joanne M. Bargman / Karl Skorecki

275 Dialysis in the Treatment of Renal Failure
Kathleen D. Liu / Glenn M. Chertow

276 Transplantation in the Treatment of Renal Failure
Charles B. Carpenter / Edgar L. Milford / Mohamed H. Sayegh

277 Glomerular Diseases
Julia B. Lewis / Eric G. Neilson

278 Polycystic Kidney Disease and Other Inherited Tubular Disorders
David J. Salant / Parul S. Patel

279 Tubulointerstitial Diseases of the Kidney
Alan S. L. Yu / Barry M. Brenner

280 Vascular Injury to the Kidney
Kamal F. Badr / Barry M. Brenner

281 Nephrolithiasis
John R. Asplin / Fredric L. Coe / Murray J. Favus

282 Urinary Tract Infections, Pyelonephritis, and Prostatitis
Walter E. Stamm

283 Urinary Tract Obstruction
Julian L. Seifter / Barry M. Brenner


Part 13
Disorders of the Gastrointestinal System

Section 1
Disorders of the Alimentary Tract

284 Approach to the Patient with Gastrointestinal Disease
William L. Hasler / Chung Owyang

285 Gastrointestinal Endoscopy
Louis Michel Wong Kee Song / Mark Topazian


e25 Video Atlas of Gastrointestinal Endoscopy
Mark Topazian

286 Diseases of the Esophagus
Raj. K. Goyal

287 Peptic Ulcer Disease and Related Disorders
John Del Valle

288 Disorders of Absorption
Henry J. Binder

289 Inflammatory Bowel Disease
Sonia Friedman / Richard S. Blumberg

290 Irritable Bowel Syndrome
Chung Owyang

291 Diverticular Disease and Common Anorectal Disorders
Susan L. Gearhart

292 Mesenteric Vascular Insufficiency
Susan L. Gearhart

293 Acute Intestinal Obstruction
Susan L. Gearhart / William Silen

294 Acute Appendicitis and Peritonitis
Susan L. Gearhart / William Silen


Section 2
Liver and Biliary Tract Disease


295 Approach to the Patient with Liver Disease
Marc Ghany /Jay H. Hoofnagle

296 Evaluation of Liver Function
Daniel S. Pratt / Marshall M. Kaplan

297 The Hyperbilirubinemias
Allan W. Wolkoff

298 Acute Viral Hepatitis
Jules L. Dienstag

299 Toxic and Drug-Induced Hepatitis
Jules L. Dienstag

300 Chronic Hepatitis
Jules L. Dienstag

301 Alcoholic Liver Disease
Mark E. Malliard / Michael F. Sorrell

302 Cirrhosis and Its Complications
Bruce R. Bacon

e26 Atlas of Liver Biopsies
Jules L. Dienstag / Atul K. Bhau

303 Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver
Bruce R. Bacon

304 Liver Transplantation
Jules L. Dienstag /Raymond T. Chung

305 Diseases of the Gallbladder and Bile Ducts
Norton J. Greenberger / Gustav Paumgartner


Section 3
Disorders of the Pancreas


306 Approach to the Patient with Pancreatic Disease
Phillip P. Toskes / Norton J. Greenberger

307 Acute and Chronic Pancreatitis
Norton J. Greenberger / Phillip P. Toskes


Part 14
Disorders of the Immune System, Connective Tissue, and Joints

Section 1
The Immune System in Health and Disease

308 Introduction to the Immune System
Barton F. Haynes / Kelly A. Soderberg / Anthony S. Fauci

309 The Major Histocompatability Complex
Gerald T. Nepom

310 Primary Immune Deficiency Diseases
Max D. Cooper / Harry W. Schroeder, Jr.

e27 Primary Immunodeficiencies Associated with or Secondary to Other Diseases
Max D. Cooper

Section 2
Disorders of Immune-Mediated Injury

311 Allergies, Anaphylaxis, and Systemic Mastocytosis
K. Frank Austen

312 Autoimmunity and Autoimmune Diseases
Peter E. Lipsky / Betty Diamond

313 Systemic Lupus Erythematosus
Bevra Hannahs Hahn

314 Rheumatoid Arthritis
Peter E. Lipsky

315 Acute Rheumatoid Fever
Jonathan R. Carapetis

316 Systemic Sclerosis (Scleroderma) and Related Disorders
John Varga

317 Sjögren’s Syndrome
Haralampos M. Moutsopoulos

318 The Spondyloarthritides
Joel D. Taurog

319 The Vasculitis Syndromes
Carol A. Langford / Anthony S. Fauci

e28 Atlas of Clinical Imaging of the Vasculitic Diseases
Carol A. Langford / Anthony S. Fauci

320 Behçet’s Syndrome
Haralampos M. Moutsopoulos

321 Relapsing Polychondritis
Carol A. Langford /Bruce C. Gilliland

322 Sarcoidosis
Robert P. Baughman /Elyse E. Lower

323 Familial Mediterranean Fever and Other Hereditary Recurrent Fevers
Daniel L. Kastner

324 Amyloidosis
David C. Seldin / Martha Skinner


Section 3
Disorders of the Joints and Adjacent Tissues

325 Approach to Articular and Musculoskeletal Disorders
John J. Cush / Peter E. Lipsky

326 Osteoarthritis
David T. Felson

327 Gout and Other Crystal Arthropathies
H. Ralph Schumacher / Lan X. Chen

328 Infectious Arthritis
Lawrence C. Madoff

329 Fibromyalgia
Carol A. Langford /Bruce C. Gilliland

330 Arthritis Associated with Systemic Disease and Other Arthritides
Carol A. Langford / Bruce C. Gilliland

331 Periarticular Disorders of the Extremities
Carol A. Langford / Bruce C. Gilliland


Part 15
Endocrinology and Metabolism

Section 1
Endocrinology


332 Principles of Endocrinology
J. Larry Jameson

333 Disorders of the Anterior Pituitary and Hypothalamus
Shlomo Melmed / J. Larry Jameson

334 Disorders of the Neurohypophysis
Gary L. Robertson

335 Disorders of the Thyroid Gland
J. Larry Jameson / Anthony P. Weetman
336 Disorders of the Adrenal Cortex
Gordon H. Williams / Robert G. Dluhy

337 Pheochromocytoma
Hartmut P.H. Neumann

338 Diabetes Mellitus
Alvin C. Powers

339 Hypoglycemia
Phillip E. Cryer

340 Disorders of the Testes and the Male Reproductive System
Shalender Bhasin / J. Larry Jameson

341 Disorders of the Ovary and Female Reproductive Tract
Janet E. Hall

342 The Menopause Transition and Postmenopausal Hormone Therapy
JoAnn E. Manson /Shari S. Bassuk

343 Disorders of Sex Development
John C. Achermann / J. Larry Jameson

344 Endocrine Tumors of the Gastrointestinal Tract and Pancreas
Robert T. Jensen

345 Disorders Affecting Multiple Endocrine Neoplasia Syndromes
Camillo Jimenez / Robert Gagel

Section 2
Disorders of Bone and Mineral Metabolism

346 Bone and Mineral Metabolism in Health and Disease
F. Richard Bringhurst / Marie B. Demay / Stephen M. Krane / Henry M. Kronenberg

347 Diseases of the Parathyroid Gland and Other Hyper- and Hypocalcemia Disorders
John T. Potts, Jr.

348 Osteoporosis
Robert Lindsay / Felicia Cosman

349 Paget Disease and Other Dysplasias of Bone
Murray J. Favus /Tamara J. Vokes

Section 3
Disorders of Intermediary Metabolism

350 Disorders of Lipoprotein Metabolism
Daniel J. Rader / Helen H. Hobbs


351 Hemochromatosis
Lawrie W. Powell

352 The Porphyrias
Robert J. Desnik / Kenneth H. Astrin

353 Disorders of Purine and Pyrimidine Metabolism
Robert L. Wortmann

354 Wilson Disease
George J. Brewer

355 Lysosomal Storage Disease
Robert J. Hopkin / Gregory A. Grabowski

356 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism
Yuan-Tsong Chen

357 Heritable Disorders of Connective Tissue
Darwin J. Prockop / Malwina Czarny-Ratajczak

358 Inherited Disoders of Amino Acid Metabolism in Adults
Nicola Longo

359 Inherited Defects of Membrane Transport
Nicola Longo

e29 Atlas of Clinical Manifestations of Metabolic Diseases
J. Larry Jameson


Part 16
Neurologic Disorders

Section 1
Diagnosis of Neurologic Disorders

360 Mechanisms of Neurologic Disorders
Stephen Hauser / M. Flint Beal

361 Approach to the Patient with Neurologic Disease
Daniel H. Lowenstein / Joseph B. Martin / Stephen L. Hauser

362 Neuroimaging in Neurologic Disorders
William P. Dillon

e30 Atlas of Neuroimaging
Andre Furtado / William P. Dillon

e31 Electrodiagnostic Studies of Nervous System Disorders: EEG and EMG
Michael J. Aminoff

e32 Technique of Lumbar Puncture
Elizabeth Robbins / Stephen L. Hauser

Section 2
Diseases of the Central Nervous System



363 Seizures and Epilepsy
Daniel H. Lowenstein

364 Cerebrovascular Diseases
Wade S. Smith / Joey English / S. Claiborne Johnston

365 Dementia
Thomas D. Bird / Bruce L. Miller

366 Parkinson’s Disease and Other Extrapyramidal Disorders
Mahlon R. DeLong / Jorge L. Juncos


367 Hyperkinetic Movement Disorders
C. Warren Olanow

368 Ataxic Disorders
Roger N. Rosenberg

369 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
Robert H. Brown, Jr.

370 Disorders of the Autonomic Nervous System
Phillip A. Low / John W. Engstrom

371 Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders
M. Flint Beal / Stephen L. Hauser

372 Diseases of the Spinal Cord
Stephen L. Hauser / Allan H. Ropper

373 Concussion and Other Head Injuries
Allan H. Ropper

374 Primary and Metastatic Tumors of the Nervous System
Stephen M. Sagar / Mark A. Israel

375 Multiple Sclerosis and Other Demyelinating Diseases
Stephen L. Hauser / Douglas S. Goodin

376 Meningitis, Encephalitis, Brain Abscess,and Empyema
Karen L. Roos / Kenneth L. Tyler

377 Chronic and Recurrent Meningitis
Walter J. Koroshetz / Morton N. Swartz

378 Prion Diseases
Stanley B. Prusiner / Bruce L. Miller


Section 3
Nerve and Muscle Disorders

379 Peripheral Neuropathy
Vinay Chaudhry

380 Guillain-Barre Syndrome and Other Immune-Mediated Neuropathies
Steven L. Hauser / Arthur K. Asbury

381 Mysathenia Gravis and Other Diseases of the Neuromuscular Junction
Daniel B. Drachman

382 An Approach to Muscular Dystrophy and Other Muscle Diseases
Robert H. Brown, Jr. / Anthony A. Amato / Jerry R. Mendell

383 Polymyositis, Dermatomyositis, and Inclusion Body Myositis
Marinos C. Dalakas

e33 Special Issues in Inpatient Neurologic Consultation
S. Andrew Josephson / Martin A. Samuels


Section 4
Chronic Fatigue Syndrome

384 Chronic Fatigue Syndrome
Stephen E. Straus


Section 5
Psychiatric Disorders

385 Biology of Psychiatric Disorders
Steve Hyman / Eric Kandel


386 Mental Disoders
Victor I. Reus


Section 6
Alcoholism and Drug Dependency


387 Alcohol and Alcoholism
Marc A. Schuckit

388 Opioid Drug Abuse and Dependence
Mark A. Schuckit

389 Cocaine and Other Commonly Abused Drugs
Jack H. Medelson / Nancy K. Mello

390 Nicotine Addiction
David M. Burns


Part 17
Poisoning, Drug Overdose, and Envenomation


e34 Heavy Metal Poisoning
Howard Hu

e35 Poisoning and Drug Overdosage
Christopher H. Linden / Michael J. Burns / Mark B. Mycyk


391 Disorders Caused by Reptile Bites and Marine Animal Exposures
Paul Auerbach / Robert Norris

e36 Ectoparasite Infestations and Arthropod Bites and Stings
Richard J. Pollack / James H. Maguire

International e Chapters

e37 Pulmonary Biomarkers in COPD
Peter J. Barnes
e38 Chagas’ Disease: Recent Advances in Diagnosis and Management
Andrei C. Sposito / Jose A.F. Ramires

Summaries of Chapters e1 to e36

Appendix

Laboratory Values of Clinical Importance
Alexander Kratz / Michael A. Pesce / Daniel J. Fink

Index

Biographical note

Anthony S. Fauci, MD, National Institute of Health, Betheseda, MD.
Eugene Braunwald, MD, Harvard Medical School, Boston, MA.
Dennis L. Kasper, MD, Harvard Medical School, Boston, MA.
Stephen L. Hauser, MD, University of California, San Francisco, CA.
Dan L. Longo, MD, National Institute of Health, Betheseda, MD.
J. Larry Jameson, MD, PhD, Northwestern University, Feinberg School of Medicine, Chicago, IL.
Joseph Loscalzo, MD, PhD, Harvard Medical School, Boston, MA.